Evaluation of amino acid substitution p. <scp>Asp183Gly</scp> of A‐glycosyltransferase enzyme in an individual with the <scp> A <sub>weak</sub> B </scp> phenotype
A novel ABO allele ABO*A1.02(548G) was identified in an A<sub>weak</sub>B individual and computational evaluation indicated that residue Asp183 was a critical site for enzyme stability and efficacy, which is consistent with the altered phenotype encoded by alleles ABO*BW.04 (c.548A>G, p.Asp183Gly) and ABO*B3.06 (c.547G>A, p.Asp183Asn).
Authors
- Yunlei He (ORCID: https://orcid.org/0000-0003-2929-5554)
- Yu Lu (ORCID: https://orcid.org/0000-0003-3944-1252)
- Jiwei Zhang (ORCID: https://orcid.org/0000-0001-8912-5069)
- Yiyu Liu (ORCID: https://orcid.org/0009-0007-7811-3290)
- Di Niu
- Fade Zhong
Institutions
- University of Nottingham Ningbo China (CN)
Publication Details
- Journal
- Transfusion
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1111/trf.18487
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00