Carnosine as a protective metabolic mediator in inflammatory lung injury by inhibiting macrophage infiltration and M1-like polarization
Our findings identify carnosine as a protective metabolic mediator in inflammatory lung injury and demonstrate its capacity to alleviate pulmonary inflammation by modulating innate immune cell recruitment and macrophage polarization. These results highlight the translational potential of carnosine as a therapeutic agent for treating inflammatory lung diseases.
Authors
- Yiming Zhuang (ORCID: https://orcid.org/0000-0001-9482-5289)
- Dandan Lin (ORCID: https://orcid.org/0000-0003-3843-6945)
- Lin Ruan (ORCID: https://orcid.org/0000-0002-0951-5006)
- Lili Zheng (ORCID: https://orcid.org/0000-0003-4540-9267)
- Bing Lin (ORCID: https://orcid.org/0000-0002-9587-7731)
- Yiming Zeng (ORCID: https://orcid.org/0000-0001-5635-3006)
- Doris Lin
- Q. Zhan
Institutions
- Fujian Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
- Putian University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fphar.2025.1689575
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00