Causal association between cigarette smoking and the prevalence of preserved ratio impaired spirometry (PRISm), and the progression risk factors of PRISm: A study based on Mendelian randomization and meta-analysis
Our findings suggest a modest causal link between cigarette smoking and PRISm prevalence. The progression of PRISm to COPD within 5 years is approximately 20.8%. Among individuals with PRISm at the first visit, 'chest distress or dyspnea' and 'current smoking' are potential clinical risk factors for the progression of PRISm to COPD.
Authors
- Xingyi Zhang (ORCID: https://orcid.org/0000-0002-5052-000X)
- Guoyue Zhang (ORCID: https://orcid.org/0000-0002-9052-5980)
- Rui Xu (ORCID: https://orcid.org/0000-0001-6236-4529)
- Ting Chen (ORCID: https://orcid.org/0000-0002-1740-9529)
- Xianzhi Du
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Tobacco Induced Diseases
- Published
- 2025-11-21
- DOI
- https://doi.org/10.18332/tid/209609
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00