Improving Clinical Generalization of Pressure Ulcer Stage Classification Through Saliency-Guided Data Augmentation

<b>Background/Objectives</b>: This study demonstrates improved generalization in pressure-ulcer stage classification. In medical imaging, training data are often scarce and disease specific. For skin conditions such as pressure ulcers, variation in camera to subject distance, resolution, illumination, and viewpoint across photographers reduces accuracy in clinical use. <b>Methods</b>: We developed a YOLOv7-based pressure ulcer stage classification model by employing a two-phase training strategy. Phase 1 was trained on the full dataset stratified by pressure-ulcer stage. Phase 2 was trained in saliency-guided images augmented with clinically plausible noise, including healing areas and white keratin. The added dataset comprised 296 images obtained by randomly sampling 30% from stages 1 through 3 of the full dataset. <b>Results</b>: The accuracy of the 38 newly acquired hospital images increased from 75% in Phase 1 to 89% in Phase 2. Five-fold cross-validation demonstrated stable performance ([email protected]: 86.20% ± 2.28%), confirming reproducibility. This exceeds by more than five percentage points the performance reported for pressure-ulcer staging models in prior studies conducted in clinical deployment settings. <b>Conclusions</b>: These findings suggest that curriculum learning combined with noise-enriched augmentation can improve generalization in clinical environments. Our results demonstrate that clinically informed data augmentation is a key factor in enhancing the model's clinical generalization. Accordingly, the proposed approach provides a practical path to enhancing clinical usability in data-limited medical imaging.