Alzheimer's disease multi‐ancestry genome‐wide interaction and stratified study with smoking
Among smokers only, a novel chromosome 12 single nucleotide polymorphism (SNP) near ANKS1B was associated with Alzheimer's disease. Evidence came from European and African ancestry cohorts. RNA-sequencing analyses implicated the top SNP as causal via ANKS1B expression in oligodendrocytes. A genome-wide African ancestry-specific significant SNP-smoking interaction was observed on chromosome 6 in SLC22A23.
Authors
- Madeline Uretsky (ORCID: https://orcid.org/0000-0002-7604-3619)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Thor D. Stein (ORCID: https://orcid.org/0000-0001-6954-4477)
- Gyungah Jun (ORCID: https://orcid.org/0000-0002-3230-8697)
- Ann Carolyn McKee (ORCID: https://orcid.org/0000-0003-2961-7488)
- Ashita S. Gurnani
- Jaeyoon Chung (ORCID: https://orcid.org/0000-0002-6431-9454)
- Li‐San Wang (ORCID: https://orcid.org/0000-0002-3684-0031)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Bobak Abdolmohammadi
- Xudong Han (ORCID: https://orcid.org/0000-0001-7961-5179)
- Max Rosenthaler (ORCID: https://orcid.org/0000-0002-4302-1691)
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- Ralph G. Dacey (ORCID: https://orcid.org/0000-0002-9181-6413)
- Annie Lee (ORCID: https://orcid.org/0000-0003-3726-6024)
- Shruti Durape
- M. Ilyas Kamboh (ORCID: https://orcid.org/0000-0002-3453-1438)
- Kathryn L. Lunetta (ORCID: https://orcid.org/0000-0002-9268-810X)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Lei Hou (ORCID: https://orcid.org/0000-0003-0540-2706)
- Margaret A. Pericak‐Vance
- Gerard Schellenberg
- David A. Bennett
- Richard Mayeux
- Jonathan L. Haines
- Mackenzie R. Paller‐Moore
Institutions
- Boston University (US)
- Rush University Medical Center (US)
- University of Miami (US)
- University of Pittsburgh (US)
- University of Washington (US)
- VA Boston Healthcare System (US)
- Framingham Heart Study (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70922
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82