Prognostic value of plasma glial fibrillary acidic protein in cognitively unimpaired older adults: Results from the A4 study
Elevated plasma glial fibrillary acidic protein (GFAP) predicted faster cognitive decline measured by Preclinical Alzheimer's Cognitive Composite (PACC). GFAP was associated with increased risk of progression to mild cognitive impairment. GFAP predicted conversion to amyloid positivity in amyloid-negative subjects. Higher baseline GFAP was associated with cortical atrophy in Alzheimer's disease (AD) -signature areas. Associations of GFAP with cognition and AD biomarkers were stronger in females.
Authors
- Richard B. Lipton (ORCID: https://orcid.org/0000-0003-2652-2897)
- Reisa Anne Sperling (ORCID: https://orcid.org/0000-0003-1535-6133)
- Ali Ezzati (ORCID: https://orcid.org/0000-0003-1307-4589)
- Joshua D. Grill (ORCID: https://orcid.org/0000-0002-4215-7589)
- Babak Khorsand (ORCID: https://orcid.org/0000-0002-1585-3909)
- S. Ahmad Sajjadi (ORCID: https://orcid.org/0000-0002-8960-2213)
- Lukai Zheng (ORCID: https://orcid.org/0000-0003-1328-2791)
- Tianchen Qian (ORCID: https://orcid.org/0000-0003-4282-7826)
- Laura A. Rabin (ORCID: https://orcid.org/0000-0002-8898-1514)
- Elham Ghanbarian
Institutions
- The Graduate Center, CUNY (US)
- Brigham and Women's Hospital (US)
- Albert Einstein College of Medicine (US)
- University of California, Irvine (US)
- Brooklyn College (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70948
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Cure Alzheimer's Fund
- National Institutes of Health
- National Institute on Aging