S1PR1-MYPT1 Maintains Coronary Endothelial Barrier in Pressure-Overloaded Hearts
These findings suggest that the S1PR1-MYPT1 signaling is crucial for coronary endothelial permeability and myocardial microenvironmental homeostasis under pressure overload, targeting which may offer therapeutic potential for related heart diseases.
Authors
- Xiu‐Ling Deng (ORCID: https://orcid.org/0000-0003-3908-6086)
- Xing Zhang (ORCID: https://orcid.org/0000-0001-6615-5038)
- Ning Huang (ORCID: https://orcid.org/0000-0001-8874-3439)
- Zheng‐Da Pang
- Gang She (ORCID: https://orcid.org/0000-0001-9700-0880)
- Xinyi Zhao (ORCID: https://orcid.org/0000-0002-5673-6661)
- Zhe Song (ORCID: https://orcid.org/0000-0001-9156-0094)
- Xinpei Wang (ORCID: https://orcid.org/0000-0002-8480-0990)
- Wenjun Xie (ORCID: https://orcid.org/0000-0003-0493-062X)
- Jing-Jing Li (ORCID: https://orcid.org/0009-0009-1619-8465)
- Y. Eugene Chen (ORCID: https://orcid.org/0009-0008-1660-434X)
- Jiahui Yao (ORCID: https://orcid.org/0009-0008-6626-9658)
- Jing Lou (ORCID: https://orcid.org/0000-0001-6224-8552)
- Yi Zhang (ORCID: https://orcid.org/0000-0003-3795-4812)
- Rui Xu (ORCID: https://orcid.org/0000-0001-5158-5393)
- Xiao‐Jun Du (ORCID: https://orcid.org/0000-0001-5213-3911)
- Fan Xu (ORCID: https://orcid.org/0000-0002-2535-0002)
- Peining Liu (ORCID: https://orcid.org/0000-0002-6447-4673)
- Yiwei Hu
Institutions
- Xi'an Honghui Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Ministry of Education (TW)
- Central Hospital of Wuhan (CN)
- Wuhan General Hospital of Guangzhou (CN)
- Xi'an Jiaotong University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25457
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00