Outcomes of extra-dose exposures of Vaughan Williams Class I or III antidysrhythmic medications

Extra-dose exposures of some antidysrhythmics belonging to Vaughan Williams Class I or III were generally well tolerated, but more data are needed to determine whether certain patients can be safely monitored at home. For example, only three cases involved Class IA drugs. Based on our findings, patients who reportedly ingest an extra dose of an antidysrhythmic plus another cardioactive medication should be evaluated at a healthcare facility.

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Publication Details

Journal
Clinical Toxicology
Published
2025-11-21
DOI
https://doi.org/10.1080/15563650.2025.2581167
Primary Topic
Poisoning and overdose treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Outcomes of extra-dose exposures of Vaughan Williams Class I or III antidysrhythmic medications

Jeanna M. Marraffa, Vince Calleo, Ahmed Alsakha, Michael Keenan et al.
Clinical Toxicology
Poisoning and overdose treatments
article

Outcomes of extra-dose exposures of Vaughan Williams Class I or III antidysrhythmic medications

Jeanna M. Marraffa, Vince Calleo, Ahmed Alsakha, Michael Keenan, Brenda Bukowiecki
article en

Abstract

Extra-dose exposures of some antidysrhythmics belonging to Vaughan Williams Class I or III were generally well tolerated, but more data are needed to determine whether certain patients can be safely monitored at home. For example, only three cases involved Class IA drugs. Based on our findings, patients who reportedly ingest an extra dose of an antidysrhythmic plus another cardioactive medication should be evaluated at a healthcare facility.

Clinical ToxicologyVol. 64(2)
Cleveland Clinic (US), SUNY Upstate Medical University (US), Abu Dhabi Health Services (AE), Upstate University Hospital (US), Washington Poison Center (US), Upstate Freshwater Institute (US), Atlantic Industries (Canada) (CA), Abu Dhabi Falcon Hospital (AE), Atlantic School of Theology (CA)
Openalex Percentile: Top 49%
Poisoning and overdose treatments
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