Influence of Retinol Dermal Delivery Formulation on Its Stability Characteristics
New cosmeceuticals formulas (direct emulsion, inverse emulsion and hydrogel), that synergistically combine bioglass with retinol, were prepared and characterized in order to attenuate the irritant potential of retinoids and prolong their therapeutic efficacy. The study evaluates the physicochemical, microbiological and stability characteristics of these formulations. Thus, TGA and DSC analyses revealed stronger interactions between water molecules and those of other organic compounds, with much more being observed in the case of emulsions than in the case of hydrogel, materialized by the delay in water evaporation. The stability of the three types of formulations has been evaluated in two ways: by determining the backscattering variation with the height of the container and analyzing the sample for 6 h and by counting the fraction of small droplets. Both methods demonstrated high stability in the three types of formulations.
Authors
- Dorin Bomboș (ORCID: https://orcid.org/0009-0001-0515-9032)
- Codruţa Saroşi (ORCID: https://orcid.org/0000-0003-2960-9832)
- Bogdan Alexandru Sava (ORCID: https://orcid.org/0000-0002-0229-9179)
- Marian Băjan (ORCID: https://orcid.org/0000-0002-5856-3944)
- Daniela Roxana Popovici (ORCID: https://orcid.org/0000-0002-3913-0350)
- Abeer Baioun (ORCID: https://orcid.org/0009-0008-4765-3937)
- Andreea-Iuliana Ionescu (ORCID: https://orcid.org/0009-0000-1494-3331)
- Gheorghe Brănoiu (ORCID: https://orcid.org/0000-0002-9562-7564)
- Cristina Maria Dușescu-Vasile (ORCID: https://orcid.org/0000-0002-2267-9531)
- Ioana Lavinia Lixandru Matei (ORCID: https://orcid.org/0000-0002-2634-0615)
- Andra-Ioana Stănică
Institutions
- Babeș-Bolyai University (RO)
- Petroleum & Gas University of Ploieşti (RO)
- National Institute for Laser Plasma and Radiation Physics (RO)
- Institutul Cantacuzino (RO)
- Universitatea Națională de Știință și Tehnologie Politehnica București (RO)
- Damascus University (SY)
- Botanical Society of America (US)
Publication Details
- Journal
- Gels
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3390/gels11120935
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00