The Neutrophil-to-Albumin Ratio (NAR) Reflects the Severity of the Post-CABG Inflammatory Response and Is Associated with a Pre-Existing Pro-Inflammatory Monocyte Profile
A patient's preoperative immune profile, specifically the degree of monocyte skew, is an independent predictor of the acute inflammatory response to CABG. This finding supports a 'priming' mechanism in high-risk patients. While NAR and NLR perform similarly as monitoring tools, the independent link between the underlying immunology and the postoperative outcome suggests that combining preoperative immunophenotyping with simple biomarker monitoring could offer a powerful new strategy for personalised risk stratification in cardiac surgery.
Authors
- Daiana Erdyneeva (ORCID: https://orcid.org/0000-0003-2279-0157)
- В. В. Донцов (ORCID: https://orcid.org/0000-0003-2904-5213)
- Sigaleva Ee (ORCID: https://orcid.org/0000-0001-9899-1604)
- Mikhail А. Popov (ORCID: https://orcid.org/0000-0002-0316-8410)
- Yegor S. Chegodaev (ORCID: https://orcid.org/0009-0005-7710-2202)
- Siarhei A. Dabravolski (ORCID: https://orcid.org/0000-0002-0547-6310)
- Ekaterina Silina (ORCID: https://orcid.org/0000-0002-0246-5149)
- Dmitriy Zybin
- Dmitriy R. Saveliev (ORCID: https://orcid.org/0009-0003-1571-4583)
- Svetlana S. Verkhova (ORCID: https://orcid.org/0000-0002-7953-0586)
- В. П. Пронина (ORCID: https://orcid.org/0000-0002-2348-1500)
- Alexander D. Zhuravlev (ORCID: https://orcid.org/0000-0002-0451-2594)
- Victor Stupin (ORCID: https://orcid.org/0000-0002-9522-8061)
- Nikita G. Nikiforov (ORCID: https://orcid.org/0000-0002-2082-2429)
- M.I. Koloteva (ORCID: https://orcid.org/0000-0002-7499-9473)
- Д. В. Шумаков (ORCID: https://orcid.org/0000-0003-4204-8865)
- Evgeniy G. Agafonov
- Olga V. Radchenkova (ORCID: https://orcid.org/0009-0004-4372-3302)
- Alexander Vladimirovich Ivanov (ORCID: https://orcid.org/0000-0002-2424-6115)
- Yegor E. Yegorov (ORCID: https://orcid.org/0000-0002-5990-4077)
- Sergei A. Vzvarov (ORCID: https://orcid.org/0009-0007-2548-7029)
- Alexandra K. Kharabet
Institutions
- Sechenov University (RU)
- Braude College of Engineering Karmiel (IL)
- Pirogov Russian National Research Medical University (RU)
- Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
- Regional Clinical Research (US)
Publication Details
- Journal
- Life
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3390/life15121790
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00