Comparative Proteomic Analysis of Aqueous Humor, Anterior Lens Capsules, and Crystalline Lenses in Different Human Cataract Subtypes Versus Healthy Controls
Comprehensive proteomic profiles were generated using DIA proteomics by comparing ARC, DC, and PVC versus controls. This is the first study to use phaco cassette contents to investigate cataract formation in comparison to controls. Our findings significantly enhance the current understanding of human cataract pathophysiology and provide novel insights into the mechanisms underlying cataract formation.
Authors
- Konstantinos I. Bougioukas (ORCID: https://orcid.org/0000-0002-6533-1391)
- Anastasios Bisoukis
- George Panayotou (ORCID: https://orcid.org/0009-0009-9538-1638)
- Konstantinos Moschou
- Marilita M. Moschos (ORCID: https://orcid.org/0000-0003-3361-9523)
- Christina Karakosta (ORCID: https://orcid.org/0000-0001-9349-4043)
- Martina Samiotaki (ORCID: https://orcid.org/0000-0001-9952-0636)
- Nantieznta Kyriakidou
Institutions
- National and Kapodistrian University of Athens (GR)
- Aristotle University of Thessaloniki (GR)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Bristol Eye Hospital (GB)
- 424 General Military Hospital (GR)
- Alexander Fleming Biomedical Sciences Research Center (GR)
Publication Details
- Journal
- Proteomes
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3390/proteomes13040062
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00