Chimeric Antigen Receptor Regulatory T Cells Targeted Against Oxidized Low-Density Lipoprotein Reduce Atherosclerotic Plaque Development
Anti-OxLDL CAR Tregs mitigate inflammation and plaque deposition associated with OxLDL and may offer a new therapeutic option for atherosclerosis.
Authors
- Shawna K. Brookens (ORCID: https://orcid.org/0000-0003-1620-6276)
- David Degaramo
- Robert D. Schwab (ORCID: https://orcid.org/0000-0001-8419-601X)
- Seok Jae Hong (ORCID: https://orcid.org/0000-0001-5360-8800)
- John T. Keane (ORCID: https://orcid.org/0009-0002-0994-5038)
- Kiran Musunuru (ORCID: https://orcid.org/0000-0003-3298-0368)
- Daniel James Rader (ORCID: https://orcid.org/0000-0002-9245-9876)
- Avery D. Posey (ORCID: https://orcid.org/0000-0001-8711-629X)
- William Aguilar (ORCID: https://orcid.org/0000-0002-0107-5253)
- Xin Bi (ORCID: https://orcid.org/0000-0002-1102-0467)
- Fang Liu (ORCID: https://orcid.org/0009-0006-1084-0427)
- Aisha Faruqi
Institutions
- Translational Therapeutics (United States) (US)
- Philadelphia VA Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1161/circulationaha.125.073987
- Citations
- 4
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.19