Clinical trial on the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Chinese males: an open-label, single and multiple dosage, parallel group study

Authors

Wen Zhong (ORCID: https://orcid.org/0000-0002-7957-7237)
Hongzhong Liu (ORCID: https://orcid.org/0000-0001-6875-3509)
Xin Xiao Zheng (ORCID: https://orcid.org/0000-0003-3027-9551)
Pei Hu (ORCID: https://orcid.org/0000-0002-7727-4902)
Tao Liu (ORCID: https://orcid.org/0000-0002-9943-2131)
Ming Rong Liu (ORCID: https://orcid.org/0000-0003-2665-4072)
Qian Zhao (ORCID: https://orcid.org/0000-0003-0304-8854)
Jiang Ji (ORCID: https://orcid.org/0000-0002-0541-4531)
Yishi Li (ORCID: https://orcid.org/0009-0001-1516-8071)

Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
National Medical Products Administration (CN)
Peking Union Medical College Hospital (CN)
Fu Wai Hospital (CN)

Publication Details

Journal: Frontiers in Pharmacology
Published: 2025-11-21
DOI: https://doi.org/10.3389/fphar.2025.1713702
Primary Topic: Electrolyte and hormonal disorders
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Otsuka Pharmaceutical
Peking Union Medical College Hospital

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article

Clinical trial on the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Chinese males: an open-label, single and multiple dosage, parallel group study

Wen Zhong, Hongzhong Liu, Xin Xiao Zheng, Pei Hu et al.

Nov 21, 2025

Frontiers in Pharmacology

Electrolyte and hormonal disorders

article

Clinical trial on the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Chinese males: an open-label, single and multiple dosage, parallel group study

Wen Zhong, Hongzhong Liu, Xin Xiao Zheng, Pei Hu, Tao Liu, Ming Rong Liu, Qian Zhao, Jiang Ji, Yishi Li

November 21, 2025article en

Abstract

No abstract available for this paper.

Frontiers in PharmacologyVol. 16

Chinese Academy of Medical Sciences & Peking Union Medical College (CN), National Medical Products Administration (CN), Peking Union Medical College Hospital (CN), Fu Wai Hospital (CN)

Otsuka Pharmaceutical, Peking Union Medical College Hospital

Openalex Percentile: Top 49%

Electrolyte and hormonal disorders

DOI Open Access PDF OpenAlex

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Clinical trial on the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Chinese males: an open-label, single and multiple dosage, parallel group study — Wen Zhong, Hongzhong Liu, et al. · Frontiers in Pharmacology (2025) | TGRS Research Map | TGRS