Additive Effects of White Matter Hyperintensity and <scp>APOE</scp> ε4 Status on Risk of Incident Dementia in Two Large Longitudinal Cohorts
WMH burden and APOE ε4 status additively increase dementia risk. These findings support the potential benefit of vascular risk management to reduce WMH and delay dementia onset, even among genetically at-risk individuals. ANN NEUROL 2026;99:656-667.
Authors
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Eric Edward Smith (ORCID: https://orcid.org/0000-0003-3956-1668)
- Cyprien A. Rivier (ORCID: https://orcid.org/0000-0002-1148-1829)
- Ian Johnson (ORCID: https://orcid.org/0000-0001-5951-6990)
- Guido J. Falcone (ORCID: https://orcid.org/0000-0002-6407-0302)
- Adam de Havenon (ORCID: https://orcid.org/0000-0001-8178-8597)
- Yvonne Kim
- Kevin Navin Sheth (ORCID: https://orcid.org/0000-0003-2003-5473)
- Eric Stulberg (ORCID: https://orcid.org/0000-0002-3075-4597)
- Santiago Clocchiatti‐Tuozzo (ORCID: https://orcid.org/0000-0001-5377-434X)
- Teresa Gómez‐Isla (ORCID: https://orcid.org/0000-0002-7977-2075)
- Shufan Huo (ORCID: https://orcid.org/0000-0002-0119-7517)
- W. Taylor Kimberly (ORCID: https://orcid.org/0000-0002-2519-8530)
- Lauren Littig (ORCID: https://orcid.org/0009-0005-7389-0328)
- Jonathan Rosand
- Sofia Constantinescu
Institutions
- University of Calgary (CA)
- Yale University (US)
- Massachusetts General Hospital (US)
- Columbia University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1002/ana.78103
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Heart Association
- Novo Nordisk
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke