Anatomical Associations Between Focal Mitochondrial Metabolism and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis
Our data indicate that brain regions with high metabolic activity are particularly vulnerable to neurodegeneration in ALS. Anatomic associations between physiological cerebral metabolism and patterns of neurodegeneration implicate mitochondrial dysfunction in the pathophysiology of ALS. Although mitochondrial dysfunction may not be the primary etiological factor, it may represent a shared bottleneck of multiple converging molecular and genetic pathways, offering a potential opportunity for meaningful pharmacological intervention. ANN NEUROL 2026;99:614-628.
Authors
- Marlene Tahedl (ORCID: https://orcid.org/0000-0003-1762-4824)
- Mark A. Doherty (ORCID: https://orcid.org/0000-0002-7423-4606)
- Orla M. Hardiman (ORCID: https://orcid.org/0000-0003-2610-1291)
- Russell Lewis McLaughlin (ORCID: https://orcid.org/0000-0003-3915-2135)
- Peter Bede (ORCID: https://orcid.org/0000-0003-0492-4772)
- Jennifer C. Hengeveld (ORCID: https://orcid.org/0000-0003-1615-324X)
- We Fong Siah (ORCID: https://orcid.org/0000-0001-8571-8246)
- Foteini Christidi (ORCID: https://orcid.org/0000-0003-1297-9415)
- Jana Kleinerová (ORCID: https://orcid.org/0000-0001-8679-8516)
- Efstratios Karavasilis (ORCID: https://orcid.org/0000-0002-7291-2231)
- Ee Ling Tan
Institutions
- National and Kapodistrian University of Athens (GR)
- Trinity College Dublin (IE)
- University General Hospital Attikon (GR)
- St. James's Hospital (IE)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1002/ana.78099
- Citations
- 2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78