Enhanced Functionality of Anti‐ <scp>GPC3 CAR</scp> ‐T Cells Against Hepatocellular Carcinoma Through Locoregional Administration
Collectively, our study demonstrates that locoregional CAR-T therapy through the portal vein is associated with increased CAR-T cell infiltration and improved therapeutic efficacy, offering promise for the treatment of both early- and late-stage patients.
Authors
- Zezhuo Su (ORCID: https://orcid.org/0000-0001-5915-1602)
- Jun Tang (ORCID: https://orcid.org/0000-0002-4540-1647)
- Chenqing Zhang
- Yaofeng Wang (ORCID: https://orcid.org/0000-0001-5554-8661)
- Guangjin Pan (ORCID: https://orcid.org/0000-0002-2378-7198)
- Kit Man Tsang
- Chenzi Zhang (ORCID: https://orcid.org/0000-0002-1911-6439)
- Bo Feng (ORCID: https://orcid.org/0000-0002-1764-8028)
- Chi Kong Li (ORCID: https://orcid.org/0000-0002-2810-5758)
- Jiale Qiu
- Jue Wang (ORCID: https://orcid.org/0000-0001-8149-1566)
Institutions
- Department of Health (CN)
- Chinese University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Liver International
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1111/liv.70450
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Innovation and Technology Fund