Ataxia Telangiectasia Mutated (ATM) gene alterations as biomarkers of response to immune checkpoint inhibitors
We demonstrated that <i>ATM</i>-mutant status is associated with longer mOS compared to <i>ATM</i>-WT and has higher predicted immunogenetic mutations. Our results are rather hypothesis-generating and would benefit from further validation in prospective trials.
Authors
- Sameer Al Diffalha
- Maun R Baral (ORCID: https://orcid.org/0000-0002-5810-6751)
- Girijesh Kumar Patel (ORCID: https://orcid.org/0000-0003-4660-5876)
- Hassan Abushukair (ORCID: https://orcid.org/0000-0002-0068-5201)
- Upender Manne
- Moh’d Khushman (ORCID: https://orcid.org/0000-0002-3095-5073)
- Maen Abdelrahim (ORCID: https://orcid.org/0000-0002-6631-5035)
- Ajay Singh (ORCID: https://orcid.org/0000-0003-2933-4058)
- Sambhawana Bhandari
- Esmail Abdullah
Institutions
- Houston Methodist (US)
- University of Miami (US)
- Motilal Nehru National Institute of Technology (IN)
- Washington University in St. Louis (US)
- Oklahoma City University (US)
- Texas Oncology (US)
- University of Mississippi Medical Center (US)
- University of Alabama at Birmingham (US)
- University of Oklahoma (US)
Publication Details
- Journal
- Immunotherapy
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1080/1750743x.2025.2590474
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00