Allergen‐Specific <scp>IgE</scp> and <scp>IgG4</scp> Signatures in <scp>IgG4</scp> ‐Related Disease Revealed by a Large‐Scale <scp>PhIP</scp> ‐Seq Study
Comprehensive pan-allergen profiling suggests distinct IgE and IgG4 signatures in IgG4-RD and links specific environmental antigens to organ-selective disease patterns. These findings support a contributory role for aberrant allergen responses in IgG4-RD pathogenesis and provide a foundation for biomarker development and targeted allergen-based interventions, especially for future mechanistic investigations.
Authors
- Ziyan Wu (ORCID: https://orcid.org/0000-0002-9774-7770)
- Linyi Peng (ORCID: https://orcid.org/0000-0002-7441-907X)
- Yongzhe Li (ORCID: https://orcid.org/0000-0002-8267-0985)
- Songxin Yan (ORCID: https://orcid.org/0000-0002-0372-6697)
- Jiaxin Zhou (ORCID: https://orcid.org/0000-0002-1664-3495)
- Haoting Zhan (ORCID: https://orcid.org/0000-0001-5934-9141)
- Jingdi Zhang (ORCID: https://orcid.org/0000-0002-4303-816X)
- Futai Feng
- Linlin Cheng (ORCID: https://orcid.org/0000-0003-1924-3363)
- Changcheng Yin (ORCID: https://orcid.org/0000-0001-7748-3205)
- Zhan Li (ORCID: https://orcid.org/0000-0001-9624-9545)
- Wen Zhang (ORCID: https://orcid.org/0000-0001-7808-9867)
- Honglin Xu
- Yunyun Fei
- Xinxin Feng (ORCID: https://orcid.org/0000-0002-1879-0253)
- Haolong Li (ORCID: https://orcid.org/0000-0002-9777-0743)
- Jialei Zhang (ORCID: https://orcid.org/0000-0002-4556-8500)
- Yongmei Liu
- Siyu Wang (ORCID: https://orcid.org/0009-0001-2719-9748)
Institutions
- Fujian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Airport Shunyi District Hospital (CN)
Publication Details
- Journal
- Allergy
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1111/all.70162
- Citations
- 2
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.34