Elucidating a novel prognostic signature for bladder cancer by integrating hypoxia and lactate metabolism-related genes: comprehensive bioinformatics analyses and experimental evidence
Our signature further illustrated heterogeneity of BLCA. This signature could predict prognosis, consensus subtypes and treatment efficacy. We believe that this signature can optimize individual treatment decisions.
Authors
- Jun Chen (ORCID: https://orcid.org/0000-0002-8037-324X)
- Zhe Shen (ORCID: https://orcid.org/0000-0003-0604-7558)
- Shengwen Yao
- Nianzhao Zhang
- Pei-Xin Li (ORCID: https://orcid.org/0000-0002-3353-6448)
- Yihao Zhao (ORCID: https://orcid.org/0009-0000-6543-6102)
- Xiaoyi Zhang
Institutions
- Jacobi Medical Center (US)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s12885-025-15010-1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province