Thermal ablation versus surgical resection for colorectal liver metastases: a Grading of Recommendations, Assessment, Development, and Evaluation (GRADE)-assessed systematic review, survival meta-analysis, and meta-regression
Surgical resection remains superior to thermal ablation in terms of OS and DFS, particularly for larger lesions (>3 cm). While thermal ablation, especially MWA, offers a promising alternative for smaller lesions, its increased risk of local recurrence warrants careful patient selection and precise procedural execution. These findings underscore the need for personalized, lesion-specific approaches to CRLM management, integrating advancements in ablation technology and hybrid surgical-ablation strategies.
Authors
- Sepideh Razi
- Uazman Alam (ORCID: https://orcid.org/0000-0002-3190-1122)
- Anwaar Saeed (ORCID: https://orcid.org/0000-0001-8024-9401)
- Asad Iqbal (ORCID: https://orcid.org/0009-0002-7726-6280)
- Santosh Rath (ORCID: https://orcid.org/0000-0003-1408-6354)
- Muhammad Burhan (ORCID: https://orcid.org/0009-0005-7034-5594)
- Noor Ul Huda Ramzan
- Muhammad Ansab
Institutions
- Services Institute of Medical Sciences (PK)
- Bacha Khan University (PK)
- Khyber Medical College (PK)
- Dow University of Health Sciences (PK)
- All India Institute of Medical Sciences Bhubaneswar (IN)
- UPMC Hillman Cancer Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.21037/tcr-2025-1726
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32