Single-cell and spatial transcriptome landscapes reveal the spatial immune defense pattern shared by primary and brain metastatic lung adenocarcinoma

This study highlights immune microenvironmental features shared between primary and metastatic tumors, particularly in the metastatic setting, and introduces TIDP as a potential framework for targeting immune evasion in brain metastases. Our findings provide a foundation for developing more targeted therapeutic strategies for patients with brain metastases from LUAD, warranting further investigation into TIDP's clinical potential.