Screening for dual-target enzyme inhibitors derived from Gardenia jasminoides roots, a medicinal and edible plant: investigation of their potential anti-dementia activity
This study integrates advanced screening, optimized extraction, and rigorous bioactivity assessment to elucidate the active components of <i>GJR</i> and their anti-AD potential. The developed methodology addresses the shortcomings of single-target drug development and provides valuable insights for the development of dual-target inhibitors and the advancement of plant-based food preparation technologies.
Authors
- Xuanlin Liu (ORCID: https://orcid.org/0000-0002-6261-6658)
- Xiangjie Bo (ORCID: https://orcid.org/0000-0002-0407-0976)
- Daqian Song (ORCID: https://orcid.org/0000-0002-4866-1292)
- Yuchi Zhang (ORCID: https://orcid.org/0000-0002-7413-7232)
- Yang Zhou (ORCID: https://orcid.org/0000-0002-2775-7586)
- Rui Meng (ORCID: https://orcid.org/0000-0002-6463-9255)
- Ming Chen (ORCID: https://orcid.org/0000-0001-5041-9342)
- Sainan Li (ORCID: https://orcid.org/0000-0002-0894-6293)
- Jingyi Han
Institutions
- Northeast Normal University (CN)
- Jilin University (CN)
- Changchun Normal University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fnut.2025.1682948
- Citations
- 1
- Primary Topic
- Saffron Plant Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.05