The Monocrotaline Model of Hypertension Leads to Cachexia in Male but Not Female Mice
These data suggest sex-dependent physiological responses of mice to MCT, where adipose tissue loss is more pronounced in males as a result of adipose tissue inflammation and metabolic activation. In contrast, conserved atrophic effects of MCT are observed within skeletal muscle, irrespective of sex. Further research using this model should consider sex-dependent responses.
Authors
- Juan F. Medrano (ORCID: https://orcid.org/0000-0001-7113-3183)
- Heather Kavanagh
- Stephanie W. Tobin (ORCID: https://orcid.org/0000-0002-5780-6238)
- Ravi Gupta (ORCID: https://orcid.org/0000-0003-2583-563X)
- Holly E. Bates (ORCID: https://orcid.org/0000-0002-3310-280X)
- Hannah C. Smith (ORCID: https://orcid.org/0000-0001-7341-2143)
- Cayleih E. Robertson (ORCID: https://orcid.org/0000-0002-6769-2852)
- Ingrid Brenner (ORCID: https://orcid.org/0000-0003-3708-8205)
- Aaron B. A. Shafer (ORCID: https://orcid.org/0000-0001-7652-225X)
- Kirk Hillsley (ORCID: https://orcid.org/0009-0005-2965-132X)
- Abbey L. Politeski
- Katherine M. Lycett
- Ben Witmer
- Noah A. Fiorucci
- Jack Cambell
Institutions
- Trent University (CA)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1002/jcsm.70129
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Sciences and Engineering Research Council of Canada