Antagonizing epigenetically controlled PAF/PAF-R pathway improves liver function during experimental cirrhosis
PAF antagonist BN-52021 disrupts PAF-R/PAF signaling counteracting PAF-R overexpression, and ameliorates liver injury in cirrhotic mice. Ptafr expression is controlled by promoter DNA demethylation leading to PAFR overexpression in hepatic macrophages.
Authors
- Rubén Francés
- Oriol Juanola (ORCID: https://orcid.org/0000-0001-7432-8808)
- Ani Gasparyan (ORCID: https://orcid.org/0000-0002-9646-9975)
- Isabel Gómez‐Hurtado (ORCID: https://orcid.org/0000-0003-4305-9427)
- Benedikt Simbrunner
- Jordi Gracia‐Sancho (ORCID: https://orcid.org/0000-0001-7736-4089)
- Sebastián Martínez‐López (ORCID: https://orcid.org/0000-0003-1720-845X)
- Esther Caparrós (ORCID: https://orcid.org/0000-0002-9681-0408)
- Enrique Ángel‐Gomis (ORCID: https://orcid.org/0000-0003-0736-7625)
- Paula Boix
- Anabel Fernández-Iglesias
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- Instituto de Salud Carlos III (ES)
- Instituto de Neurociencias (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.biopha.2025.118804
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00