Selective Reductive Amination of Carbonyls to Primary Amines Under Ambient Conditions Over Rh/MFM‐300(Cr)

Abstract The synthesis of organic amines via reductive amination of biomass‐derived carbonyl compounds is an important target for sustainable chemical industries. The control of selectivity for the formation of primary amines versus secondary amines is challenging, and high temperature and pressures using H 2 are required to generate the desired selectivity. Herein, we report the highly selective reductive amination of a broad range of aldehydes and ketones by NH 3 and H 2 over Rh/MFM‐300(Cr) to form primary amines with a selectivity of up to 99% under ambient conditions. Inelastic neutron scattering reveals that the Rh species not only promote the hydrogenation process, but also catalyzes the ammonolysis of the Schiff base intermediate, facilitating the selective synthesis of primary amines. This protocol achieves selective reductive amination at 25 °C and 1 atm, providing an energy‐efficient route to a broad spectrum of amines.

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Publication Details

Journal
Angewandte Chemie
Published
2025-11-20
DOI
https://doi.org/10.1002/ange.202519641
Primary Topic
Asymmetric Hydrogenation and Catalysis
Type
article
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article

Selective Reductive Amination of Carbonyls to Primary Amines Under Ambient Conditions Over Rh/MFM‐300(Cr)

Svemir Rudić, Shaojun Xu, Bing An, Sihai Yang⧫ et al.
Angewandte Chemie
Asymmetric Hydrogenation and Catalysis
article

Selective Reductive Amination of Carbonyls to Primary Amines Under Ambient Conditions Over Rh/MFM‐300(Cr)

Svemir Rudić, Shaojun Xu, Bing An, Sihai Yang⧫, Rongsheng Cai, Qingqing Mei, Martin Schröder, Sarah J. Haigh, Wenyuan Huang, Xue Han, Longfei Lin, Buxing Han
article en

Abstract

Abstract The synthesis of organic amines via reductive amination of biomass‐derived carbonyl compounds is an important target for sustainable chemical industries. The control of selectivity for the formation of primary amines versus secondary amines is challenging, and high temperature and pressures using H 2 are required to generate the desired selectivity. Herein, we report the highly selective reductive amination of a broad range of aldehydes and ketones by NH 3 and H 2 over Rh/MFM‐300(Cr) to form primary amines with a selectivity of up to 99% under ambient conditions. Inelastic neutron scattering reveals that the Rh species not only promote the hydrogenation process, but also catalyzes the ammonolysis of the Schiff base intermediate, facilitating the selective synthesis of primary amines. This protocol achieves selective reductive amination at 25 °C and 1 atm, providing an energy‐efficient route to a broad spectrum of amines.

Angewandte ChemieVol. 137(52)
Rutherford Appleton Laboratory (GB), Peking University (CN), Beijing Normal University (CN), University of Manchester (GB), Beijing National Laboratory for Molecular Sciences (CN), Zhejiang University (CN)
Openalex Percentile: Top 70%
Asymmetric Hydrogenation and Catalysis
DOIOpen Access PDFOpenAlex
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