Daflon attenuates cisplatin-induced cerebellar neurotoxicity, anxiety-like behavior, and motor dysfunction by downregulating TLR4/NF-kB signaling
In conclusion, daflon confers neuroprotection against cisplatin-induced cerebellar neurotoxicity through the suppression of TLR4/NF-kB-mediated oxidative-inflammatory and apoptotic injury.
Authors
- Olubunmi Ajao
- Roland Eghoghosoa Akhigbe (ORCID: https://orcid.org/0000-0002-3874-5927)
- Aishat Oladipo (ORCID: https://orcid.org/0000-0002-9815-5566)
- Olusegun A. Adepoju
- Olufemi Adeleye
- Fredah Batale Fidelis
- P A Oyedokun (ORCID: https://orcid.org/0000-0003-0659-1086)
- Tunmise Maryanne Akhigbe (ORCID: https://orcid.org/0000-0002-8762-3395)
- Oluwaseyi Esther Ogundipe
- Abiodun Shukrat Lasisi-Sholola
Institutions
- Ahmadu Bello University (NG)
- Osun State University (NG)
- Hospital Samaritano de São Paulo (BR)
- Ladoke Akintola University of Technology (NG)
- Lead City University (NG)
- Federal Police of Brazil (BR)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s40360-025-01046-3
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00