Clinical significance of non-invasive in vitro drug sensitivity profiling using pancreatic cancer organoids derived from saline flushes collected during routine EUS-FNA
This study demonstrated the feasibility and potential usefulness of in vitro drug sensitivity profiling of pancreatic cancer using RSSF-derived PDCOs. These findings represent the first step toward clinical application, and further validation in larger cohorts is warranted.
Authors
- Makiko Urabe (ORCID: https://orcid.org/0009-0009-8033-3158)
- Shigenori Nagata (ORCID: https://orcid.org/0000-0002-5455-6886)
- Yugo Kai
- Hideaki Tahara (ORCID: https://orcid.org/0000-0002-1735-5372)
- Ryoji Takada (ORCID: https://orcid.org/0000-0002-6568-8091)
- Tomoya Ekawa (ORCID: https://orcid.org/0009-0005-4222-4736)
- Kenji Ikezawa (ORCID: https://orcid.org/0000-0001-7517-8960)
- Takashi Akazawa (ORCID: https://orcid.org/0000-0002-4155-9228)
- Kumiko Tatsumi (ORCID: https://orcid.org/0009-0002-9300-183X)
- Yoji Kukita (ORCID: https://orcid.org/0000-0003-3523-2816)
- Hisataka Ogawa (ORCID: https://orcid.org/0000-0002-9317-5007)
- Kazuyoshi Ohkawa (ORCID: https://orcid.org/0000-0001-9700-2472)
- Hidenori Takahashi (ORCID: https://orcid.org/0000-0003-4801-3540)
- Yu Mizote (ORCID: https://orcid.org/0009-0006-9662-322X)
- Shinichiro Hasegawa (ORCID: https://orcid.org/0000-0001-8117-8350)
Institutions
- Kyoto University (JP)
- Osaka International Cancer Institute (JP)
- Kyoto University Hospital (JP)
- Osaka International Cancer Institute (JP)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1007/s12094-025-04111-9
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science