Organoid‐based two‐step drug screening for rapid identification of chemotherapy‐resistant oesophageal squamous cell carcinoma and alternative therapies
This method exhibits strong clinical applicability, supporting more accurate and timely decision-making in ESCC management. The C<sub>max</sub>/GR100-based drug screening strategy can dynamically identify alternative sensitive drugs for patients who fail first-line therapies, enabling precise re-treatment. This approach provides a valuable tool for translating laboratory findings into clinical practice.
Authors
- Wei Deng (ORCID: https://orcid.org/0000-0001-7487-8519)
- Xin Tong (ORCID: https://orcid.org/0000-0003-4408-3832)
- Li Yu (ORCID: https://orcid.org/0000-0002-1054-017X)
- Jun Zhao (ORCID: https://orcid.org/0000-0001-8903-8205)
- Yuan‐Lu Cui (ORCID: https://orcid.org/0000-0003-4392-3713)
- Cheng Ding (ORCID: https://orcid.org/0000-0001-7760-1814)
- Chang Li (ORCID: https://orcid.org/0000-0002-9469-7173)
- Jian Yang (ORCID: https://orcid.org/0000-0003-4604-5901)
- Yufeng Xie (ORCID: https://orcid.org/0000-0003-0171-9458)
- Sheng Ju
- Kang Hu
- Songbing Qin (ORCID: https://orcid.org/0000-0001-7056-1741)
- Chenye Shao
- Yi‐xian Zhu (ORCID: https://orcid.org/0009-0007-3701-371X)
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/ctm2.70534
- Citations
- 1
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province