Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway
EPE exerts anti- HCC effects by activating NK cells through the activation of the cGAS-STING signaling pathway. This suggests that EPE may serve as a potential immunotherapeutic agent, offering novel therapeutic perspectives for the treatment of HCC.
Authors
- Zhaofang Bai (ORCID: https://orcid.org/0000-0003-1049-6882)
- Yuanyuan Guo (ORCID: https://orcid.org/0000-0002-5122-8545)
- Xueting Wang (ORCID: https://orcid.org/0000-0002-0524-8545)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Li Liu (ORCID: https://orcid.org/0000-0003-2566-7357)
- Liu Li (ORCID: https://orcid.org/0000-0002-4898-3013)
- Xiaohe Xiao (ORCID: https://orcid.org/0000-0002-3719-6575)
- Xianling Wang (ORCID: https://orcid.org/0000-0001-7350-4101)
- Zhan Xiaoyan
- Haibo Cheng
- Jincai Wen
- Caiping He
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- The Synergetic Innovation Center for Advanced Materials (CN)
- Chinese People's Liberation Army (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fphar.2025.1681650
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Nanjing University of Chinese Medicine
- Nanjing University
- Beijing Nova Program