OXTR rs2254298 polymorphism influences escitalopram response in Generalized Anxiety Disorder: a sex-specific role for oxytocin signaling
Our findings suggest that the OXTR rs2254298 polymorphism may influence escitalopram response in GAD via OT neuroendocrine mechanisms, exhibiting prominent sexual dimorphism. Integrating genetic profiling with endocrine biomarkers holds promise for personalizing anxiety treatment.
Authors
- Hongfen Ni
- Hong Dai (ORCID: https://orcid.org/0000-0002-3009-5536)
- Xue Liang (ORCID: https://orcid.org/0000-0001-7134-0182)
Institutions
- Huzhou Vocational and Technical College (CN)
- Huzhou Central Hospital (CN)
- Third People's Hospital of Huzhou (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fpsyt.2025.1718106
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00