Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice
Follistatin plays a protective role in mice by maintaining the metabolic health of skeletal muscles; it restores muscle function during HFD challenge, thereby reducing diet-induced obesity-related complications.
Authors
- Koichi Ikuta (ORCID: https://orcid.org/0000-0003-1319-1021)
- Shinya Abe (ORCID: https://orcid.org/0000-0002-2707-1947)
- Toshihiko Satake (ORCID: https://orcid.org/0000-0002-4122-628X)
- Yoshiyuki Watanabe (ORCID: https://orcid.org/0000-0001-9037-3596)
- Takumi Era (ORCID: https://orcid.org/0000-0003-2693-1914)
- Sana Khalid (ORCID: https://orcid.org/0000-0003-4361-2368)
- Tomonobu Kado (ORCID: https://orcid.org/0000-0002-7750-3023)
- Ayumi Nishimura
- Kaoru Hirabayashi (ORCID: https://orcid.org/0000-0002-6682-1931)
- Hiroyuki Miwa (ORCID: https://orcid.org/0000-0001-6899-7028)
- Martin Matthew Matzuk (ORCID: https://orcid.org/0000-0002-1445-8632)
- Shiho Fujisaka (ORCID: https://orcid.org/0000-0003-0554-9003)
- Masaru Kato (ORCID: https://orcid.org/0000-0003-1724-5824)
- Muhammad Rahil Aslam (ORCID: https://orcid.org/0000-0003-0684-9147)
- Isao Usui (ORCID: https://orcid.org/0000-0002-4720-4882)
- Kazuyuki Tobe
- Maki Yokoyama (ORCID: https://orcid.org/0000-0001-7942-6677)
- Yasuhiro Onogi (ORCID: https://orcid.org/0000-0002-7950-8952)
- Naeem Iqbal
- Muhammad Bilal
- Allah Nawaz
- Seiji Yamamoto (ORCID: https://orcid.org/0000-0003-1007-6271)
- Yoshiko Igarashi (ORCID: https://orcid.org/0000-0003-4627-1394)
- Memoona Memoona
- Nguyen Quynh Phuong
- Le Duc Anh
- Kohta Kobayashi
Institutions
- Joslin Diabetes Center (US)
- Harvard University (US)
- Rawalpindi Medical University (PK)
- Baylor College of Medicine (US)
- Kyoto University (JP)
- Phenikaa University (VN)
- University of Toyama (JP)
- Dokkyo Medical University (JP)
- Saitama Medical University (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s10020-025-01393-1
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00