Efficacy and safety of postoperative radiotherapy in locally advanced esophageal squamous cell carcinoma patients with pathologic incomplete response after neoadjuvant immunochemotherapy: a retrospective cohort study
Mediastinal and supraclavicular lymph node metastasis remains the primary cause of treatment failure in LA-ESCC patients with non-pCR after NICT and without PORT. PORT significantly improves DFS in patients with high-risk clinicopathological features or poor response to NICT, and demonstrates a favorable safety profile, indicating an effective adjuvant treatment strategy for improving prognosis.
Authors
- Fengjun Liu
- Yiming Mu (ORCID: https://orcid.org/0000-0002-3344-3540)
- Dianzheng An
- Pingping Hu
- Jiandong Zhang
- Yan Zhang (ORCID: https://orcid.org/0000-0003-0727-7697)
- Jingxin Zhang (ORCID: https://orcid.org/0000-0002-4659-9624)
- Jian Xie (ORCID: https://orcid.org/0009-0002-8590-9725)
- Ning Liang (ORCID: https://orcid.org/0000-0003-0260-2331)
- Lili Qiao
- Xue Wu (ORCID: https://orcid.org/0009-0002-0600-0223)
- Yuying Hao
- Shunshun Bao
- Guodong Deng
- Fangjie Ding
Institutions
- Shandong University (CN)
- Shandong Tumor Hospital (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1660097
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province
- Shandong First Medical University
- Shandong Academy of Medical Sciences
- Wu Jieping Medical Foundation