PARP9 drives the malignant progression of pancreatic cancer cells by regulating apoptosis, DNA damage, and multidrug efflux systems
Our study reveals a potential link between PARP9 and PC, and targeting PARP9 and LOXL2 in monotherapy or combination therapy may provide novel strategies to advanced PC.
Authors
- Xing Wang (ORCID: https://orcid.org/0000-0003-3356-9108)
- Xiaolong Liu (ORCID: https://orcid.org/0000-0001-7358-0366)
- Yulan Li (ORCID: https://orcid.org/0000-0002-3945-2157)
Institutions
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fcell.2025.1694345
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00