Pathogen spectrum, clinical traits and exploration of mortality outcome-improving medication regimens in coinfection patients with severe fever with thrombocytopenia syndrome: a multicenter cohort study

This study found a high proportion of SFTS patients with coinfection, which significantly worsens their clinical prognosis. SFTS currently has no specific therapy; clinical treatment focuses on symptomatic and supportive care, with strict standardization for antibiotics and antifungal use, and attention to patients' nutritional support. Albumin is a key protective factor associated with a lower risk of coinfection in SFTS patients; combined use of human albumin and corticosteroids was associated with a further trend toward better clinical prognosis in coinfected patients.

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Publication Details

Journal
Frontiers in Cellular and Infection Microbiology
Published
2025-11-21
DOI
https://doi.org/10.3389/fcimb.2025.1708979
Citations
1
Primary Topic
Viral Infections and Vectors
Type
article
Field-Weighted Citation Impact
1.40

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article

Pathogen spectrum, clinical traits and exploration of mortality outcome-improving medication regimens in coinfection patients with severe fever with thrombocytopenia syndrome: a multicenter cohort study

Qun Li, Wei Zhou, Yong Zhou, Yuanni Liu et al.
1 citations
Frontiers in Cellular and Infection Microbiology
Viral Infections and Vectors
1.40
article

Pathogen spectrum, clinical traits and exploration of mortality outcome-improving medication regimens in coinfection patients with severe fever with thrombocytopenia syndrome: a multicenter cohort study

Qun Li, Wei Zhou, Yong Zhou, Yuanni Liu, Lianhe Lu, Zhihai Chen, Chao Zhao, Ling Lin, Wei Zhang, Zibo Fan, Jianping Duan, Yi Shen, Zhenghua Zhao
article en
1 citations

Abstract

This study found a high proportion of SFTS patients with coinfection, which significantly worsens their clinical prognosis. SFTS currently has no specific therapy; clinical treatment focuses on symptomatic and supportive care, with strict standardization for antibiotics and antifungal use, and attention to patients' nutritional support. Albumin is a key protective factor associated with a lower risk of coinfection in SFTS patients; combined use of human albumin and corticosteroids was associated with a further trend toward better clinical prognosis in coinfected patients.

Frontiers in Cellular and Infection MicrobiologyVol. 15
Qingdao University (CN), Beijing Anding Hospital (CN), Qingdao Municipal Hospital (CN), Yantaishan Hospital (CN), Beijing Ditan Hospital (CN), Taian City Central Hospital (CN), Qingdao Eighth People's Hospital (CN), Seventh People's Hospital of Dalian (CN), Eastern Liaoning University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 14%
Viral Infections and Vectors
1.40
DOIOpen Access PDFOpenAlex
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