NETs promote invasive behavior of fibroblast-like synoviocytes through GPIbα in rheumatoid arthritis
Our findings reveal that NETs promote RA progression by inducing FLS proliferation and migration through GPIbα. Consequently, targeting NETs formation or GPIbα represents a promising therapeutic strategy to mitigate RA.
Authors
- Yue Sun (ORCID: https://orcid.org/0000-0002-0807-9847)
- Yongqiang Zhang (ORCID: https://orcid.org/0000-0002-3961-2536)
- Bing Pan (ORCID: https://orcid.org/0000-0001-8907-8100)
- Xuanqi Liu (ORCID: https://orcid.org/0000-0003-4275-9712)
- Congzhu Ding (ORCID: https://orcid.org/0000-0002-1365-4172)
- Yingyi Wu (ORCID: https://orcid.org/0000-0003-3966-785X)
- Hui Yang (ORCID: https://orcid.org/0000-0001-8485-1029)
- Lingyun Sun
Institutions
- Henan University Huaihe Hospital and Huaihe Clinical Institute (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1667319
- Citations
- 2
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.59