Development and validation of a two-dimensional liquid chromatography method for therapeutic drug monitoring of pyrotinib in human plasma
The developed 2D-LC analytical method not only demonstrates good precision, accuracy, recovery, and stability, but also is simple, rapid, feasible, and practical for TDM. It can be used for the concentration monitoring of pyrotinib in clinic, providing more scientific evidence for clinical practice.
Authors
- Haisheng You
- Mengna An
- Yuzhi Cao
- Chunxia Gao (ORCID: https://orcid.org/0000-0002-5251-9213)
- Jian‐Hui Lan (ORCID: https://orcid.org/0000-0003-0654-8483)
- Zhihui Li (ORCID: https://orcid.org/0000-0002-4998-1909)
- Siying Chen (ORCID: https://orcid.org/0000-0002-0111-3889)
- Chao Meng
Institutions
- The People's Hospital Tongling (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Hospital of Xi'an (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fphar.2025.1704594
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Key Research and Development Projects of Shaanxi Province