Anti-inflammatory and analgesic effects of Kaihoujian throat spray, and therapeutic mechanism in acute pharyngitis: involvement of the NF-κB/COX-2 pathway and formula deconstruction strategy
This study confirmed the potent anti-inflammatory and analgesic effects of the Miao medicine KHJ and its efficacy in treating acute pharyngitis. It was novel in reporting the complete KHJ formula as significantly superior to its individual components, thereby underscoring the vital role of integrated formulation design. Furthermore, the therapeutic effect was mechanistically associated with inhibition of the COX-2/NF-κB signaling pathway. These findings provide a scientific foundation for the clinical application of KHJ and validate the rationale of Miao medicine compatibility.
Authors
- Tingting Feng (ORCID: https://orcid.org/0000-0002-6282-1555)
- chang liu (ORCID: https://orcid.org/0000-0001-5869-6264)
- Ying Zhou (ORCID: https://orcid.org/0000-0002-1817-1719)
- Jinhe Zhang (ORCID: https://orcid.org/0000-0001-5770-2976)
- Hui Shi (ORCID: https://orcid.org/0000-0002-0104-8212)
- Xiongwei Liu (ORCID: https://orcid.org/0000-0002-9005-260X)
- Dong Xiu
- Liyan Zhang (ORCID: https://orcid.org/0000-0002-4105-0704)
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
- Guizhou University (CN)
- Anshun University (CN)
- Guizhou Magic Pharmaceutical (China) (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fphar.2025.1687046
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00