Mechanism and research progress of MAPK signaling pathway in myocardial fibrosis
Myocardial fibrosis (MF) is a hallmark pathological outcome of many cardiovascular diseases and a key component of cardiac remodeling. The p38 MAPK, JNK, and ERK signaling pathways are central to this process. This review summarizes the roles and interactions of these factors in MF and identifies relevant drug and non-pharmacological therapies targeting these pathways.
Authors
- Yao Sun (ORCID: https://orcid.org/0000-0002-4323-0506)
- Ze Peng (ORCID: https://orcid.org/0000-0003-1665-3519)
- Jinqiao Wu (ORCID: https://orcid.org/0000-0003-3266-2554)
- Min Chen (ORCID: https://orcid.org/0000-0001-8645-5193)
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fcvm.2025.1667568
- Citations
- 2
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 2.78