Different phenotypes of severe flares in patients with systemic lupus erythematosus: results of a clustering analysis in a monocentric cohort
We described three different clusters of severe flares in SLE in a real-life setting, identifying a hyper-inflammatory flare phenotype, that shares a comparable proportion of unsatisfying response to treatment as renal flares. Our results may represent a clinical starting point, in the context of precision medicine, for better characterization of severe non-renal disease of SLE, with the final aim of setting up early tailored treatment strategies.
Authors
- Viola Signorini
- C. Cardelli
- R. Zas
- Elena Elefante (ORCID: https://orcid.org/0000-0003-0657-485X)
- M. Mosca
- Davide Schiliró (ORCID: https://orcid.org/0009-0003-9214-617X)
- Carlo E. Stagnaro (ORCID: https://orcid.org/0009-0001-1904-0091)
- Linda Carli (ORCID: https://orcid.org/0000-0002-1664-4877)
- G. Cascarano
- C. Tani
- Michele Maffi (ORCID: https://orcid.org/0000-0002-1482-1809)
- D. Zucchi
- Maria Laura Manca (ORCID: https://orcid.org/0000-0002-9274-2313)
- Francesco Ferro (ORCID: https://orcid.org/0000-0003-2834-9768)
Institutions
- University of Pisa (IT)
- Research Institute Hospital 12 de Octubre (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1673350
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67