Exploring the role of febuxostat’s drug target XOR in erectile dysfunction: insights from human genetics and rat models
FB reducing oxidative stress and apoptosis in penile corpus cavernosum tissue in hyperuricemic rats by inhibiting XOR, thereby ameliorates ED.
Authors
- Qingfu Deng (ORCID: https://orcid.org/0009-0008-4836-9495)
- Chunyang Meng (ORCID: https://orcid.org/0000-0002-3334-9503)
- Tao Zhou (ORCID: https://orcid.org/0000-0003-1295-8331)
- Yang Zeng (ORCID: https://orcid.org/0000-0002-3651-042X)
- Xiong Li (ORCID: https://orcid.org/0000-0003-1875-5666)
- Xu Li (ORCID: https://orcid.org/0000-0002-7893-0457)
- Zhibin Chen (ORCID: https://orcid.org/0000-0002-2354-6589)
- Huan Liao (ORCID: https://orcid.org/0000-0001-9335-3881)
- Yuqi Li (ORCID: https://orcid.org/0000-0003-4629-4027)
- Xiaorong Li
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- Sichuan Mianyang 404 Hospital (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Neijiang Normal University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fmed.2025.1674086
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Southwest Medical University
- Luzhou Science and Technology Bureau