Introducing an innovative IMPT algorithm toward clinic implementation of the MCF MKM RBE model for carbon ion therapy
This proof-of-principle study confirmed the feasibility of using a randomized gradient-free method to optimize RBE dose based on the MCF MKM in IMPT planning for carbon ion therapy. The approach provides a pathway for clinical adoption of advanced RBE models, potentially leading to more biologically informed and effective carbon ion therapy treatments. Future work involves refining algorithms, incorporating parallel computing, and performing additional case studies to improve computational efficiency and generalizability.
Authors
- Dong Han (ORCID: https://orcid.org/0000-0003-4010-1220)
- Chris Beltran (ORCID: https://orcid.org/0000-0001-7688-0815)
- Chunjoo Park
- Xiaoying Liang (ORCID: https://orcid.org/0000-0002-6688-1045)
- Jiahong Lu (ORCID: https://orcid.org/0000-0002-1147-125X)
- Sridhar Yaddanapudi (ORCID: https://orcid.org/0000-0001-9796-8576)
- Keith M. Furutani (ORCID: https://orcid.org/0000-0002-6794-2540)
- Hongcheng Liu (ORCID: https://orcid.org/0000-0003-2451-5204)
- Yu Yang (ORCID: https://orcid.org/0000-0002-0502-7603)
- Jun Tan (ORCID: https://orcid.org/0000-0001-9317-1949)
- P. Alessio
- Jianzhong Tong
Institutions
- Jacksonville College (US)
- University of Florida (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Medical Physics
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1002/mp.70148
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00