Unraveling the gastrointestinal tract's response to alcohol binges: Neutrophil recruitment, neutrophil extracellular traps, and intestinal injury
Alcohol binges result in a PSI enteropathy, transient infiltration of neutrophils, and NETs that are independent of ROS production. Treatment with DNase, a nonspecific inhibitor of NETs, mitigates alcohol-induced PSI enteropathy, neutrophil recruitment and bacterial translocation.
Authors
- Scott B. Minchenberg (ORCID: https://orcid.org/0000-0002-0445-5956)
- Gyöngyi Szabó (ORCID: https://orcid.org/0000-0003-0836-2527)
- Veronika Brezáni (ORCID: https://orcid.org/0000-0003-2980-6334)
- Prashanth Thevkar Nagesh (ORCID: https://orcid.org/0000-0001-9928-9905)
- Subhash Kulkarni (ORCID: https://orcid.org/0000-0002-2298-0623)
- Alejandro H. Gutierrez (ORCID: https://orcid.org/0000-0003-3086-1971)
- Aditi Ashish Datta (ORCID: https://orcid.org/0009-0002-4161-2815)
- Miquel Ribera
- Su Min Hong (ORCID: https://orcid.org/0009-0006-8472-9924)
- Bruna dos Santos (ORCID: https://orcid.org/0000-0002-4240-9571)
Institutions
- Broad Institute (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1111/acer.70196
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00