Unravelling the significance of natural products with antiosteoporetic action: a recent review

Abstract Introduction Degeneration of bone microarchitecture and decreased bone mineral density are hallmarks of osteoporosis, a prevalent skeletal disorder. The promise of natural compounds derived from medicinal plants as safe and efficient treatments has drawn attention due to the drawbacks and adverse effects of existing pharmaceutical medicines. Therefore, knowledge of medicinal plants and phytochemicals with antiosteoporosis potential is crucial. Thus, this article’s goal was to compile the mechanisms and efficacy of medicinal plants and their many types of phytochemicals in the fight against osteoporosis. Content This article reviews current studies on natural substances with anti-osteoporosis properties, discussing their mechanisms such as regulating bone resorption, preventing osteoclastogenesis, encouraging osteoblast differentiation, and reducing inflammatory processes from sources like ScienceDirect, Google Scholar and PubMed. Summary Flavonoids, polyphenols, alkaloids, terpenoids, and vitamins are naturally occurring compounds with promising anti-osteoporotic properties. They inhibit NF-κB, PI3K/Akt, MAPK, and Wnt/β-catenin pathways, regulating bone turnover and inhibiting resorption. Some phytochemicals also protect bones with antioxidant and anti-inflammatory properties. However, challenges remain in translating these findings into clinical practice. Outlook By finding natural products that help fight osteoporosis, this review seeks to increase therapy choices, especially for older persons with osteoporosis. These therapies may lessen health issues, enhance wellbeing, and provide an affordable substitute for pricey prescription drugs. People with chronic illnesses may find natural products attractive since they may have fewer adverse effects than synthetic medications.