Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses
Given the lack of significant effects on direct DNA repair or transcriptomic responses, our findings suggest that HSP90 inhibition radiosensitizes NET cells by inducing a pleiotropic effect on multiple stress-related pathways at the protein level, rather than solely through disruption of DNA damage response mechanisms. This effect is likely driven by loss of HSP90 function and subsequent cumulated unfolded protein and proteotoxic stress.
Authors
- Nicole S. Verkaik
- Thom G. A. Reuvers (ORCID: https://orcid.org/0000-0003-3989-3312)
- Jiang Chang (ORCID: https://orcid.org/0000-0002-8300-8723)
- Pleun A.M. Engbers (ORCID: https://orcid.org/0009-0007-2492-0943)
- José María Heredia‐Genestar (ORCID: https://orcid.org/0000-0002-7970-5016)
- Mariangela Sabatella (ORCID: https://orcid.org/0000-0002-9177-4946)
- Julie Nonnekens (ORCID: https://orcid.org/0000-0002-9644-7522)
Institutions
- Erasmus MC (NL)
- Erasmus MC Cancer Institute (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1186/s13550-025-01346-z
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00