Therapeutic Plasma Exchange Resolves Inflammation With Increased <scp> <i>HSD11B1</i> </scp> in Kawasaki Disease
Kawasaki disease (KD) is an acute inflammatory disorder in children. The important complication of coronary artery aneurysms occurs in treatment-resistant patients. Therapeutic plasma exchange (TPE) has been effective for some refractory KD. Here, we investigated the effectiveness of TPE and how the glucocorticoid amplifying enzyme, 11beta-hydroxysteroid dehydrogenase 1, is involved in the resolution of inflammation in refractory KD.
Authors
- Soichiro Wada (ORCID: https://orcid.org/0000-0002-3088-1510)
- Kiyoshi Nagumo
- Shuji Sai (ORCID: https://orcid.org/0000-0002-5162-1371)
- Shigetoshi Ogiwara (ORCID: https://orcid.org/0000-0001-9650-5852)
- Karen E. Chapman (ORCID: https://orcid.org/0000-0001-7777-6817)
- Takuya Tamura
Institutions
- Hokkaido University (JP)
- Teine Keijinkai Hospital (JP)
- The Queen's Medical Research Institute (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Journal of Clinical Apheresis
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1002/jca.70076
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00