Prognostic analysis of cerebral microbleeds in patients with large artery atherosclerotic stroke without thrombolytic therapy

The presence of CMBs, particularly in deep or infratentorial regions, significantly worsens the prognosis of LAAS patients without thrombolytic therapy. Patients with CMBs have a higher risk of recurrent IS and all-cause mortality, but no significant difference in ICH incidence compared to those without CMBs. CMB burden had no differential effect on the efficacy of single antiplatelet therapy (SAPT) or double antiplatelet therapy (DAPT). Further prospective studies are necessary to validate these findings and explore alternative therapeutic strategies.