Single-nuclei RNA sequencing unveils astrocyte and oligodendrocyte lineage cells in post-stroke human brain
This study provides a peri-infarct human cortical snRNA-seq atlas after IS, revealing coordinated glial transcriptional responses that promote cellular adaptation and repair. The upregulation of NMNAT2, HIF3A, NRP1, SEZ6L, and GPM6A highlights potential therapeutic targets for enhancing neuroprotection and remyelination after stroke.
Authors
- Lina Qiu (ORCID: https://orcid.org/0000-0002-4417-0226)
- Jieli Chen (ORCID: https://orcid.org/0000-0001-5446-9101)
- Jialing Wu (ORCID: https://orcid.org/0000-0002-7923-1930)
- Shupeng Sun
- Yanqin Geng (ORCID: https://orcid.org/0000-0001-7969-1534)
- Yao Xiuhua (ORCID: https://orcid.org/0009-0002-3801-7759)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-3919-7037)
- Ying Cai (ORCID: https://orcid.org/0000-0002-2092-8813)
- Zhongzhen Li
- Fang Guo
- Tao Chen
- Yilin Ma
- Chengcheng Zhao (ORCID: https://orcid.org/0000-0002-8841-5424)
Institutions
- Shanghai Jiao Tong University (CN)
- Tianjin Huanhu Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Experimental Neurology
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1016/j.expneurol.2025.115550
- Citations
- 1
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.32