Consolidation ICIs Alter cardiac subregion radiosensitivity in NSCLC patients treated with Chemo-Radiotherapy
Doses to the SAN and the base of the heart correlate with RIHD in CRT patients, while doses to LV in CRT + ICI patients. While the 2-6 % increased risk per Gy seems modest, it is clinically significant as the subregions, being small structures, can potentially be completely spared with a carefully optimized plan.
Authors
- Jaeho Cho (ORCID: https://orcid.org/0000-0001-9966-5157)
- Gowoon Yang (ORCID: https://orcid.org/0000-0001-9203-2920)
- Seo‐Yeon Gwak (ORCID: https://orcid.org/0000-0002-5550-4156)
- Yejin Kim (ORCID: https://orcid.org/0000-0002-3416-1502)
- Joongyo Lee (ORCID: https://orcid.org/0000-0002-1747-9869)
- Clemens Grassberger (ORCID: https://orcid.org/0000-0002-4425-4489)
- Bonnie Ky (ORCID: https://orcid.org/0000-0002-6628-9981)
- Hong In Yoon (ORCID: https://orcid.org/0000-0002-2106-6856)
- Chang Geol Lee (ORCID: https://orcid.org/0000-0002-8702-881X)
- Kyung Hwan Kim (ORCID: https://orcid.org/0000-0002-6713-1350)
- Jin Sung Kim (ORCID: https://orcid.org/0000-0003-1415-6471)
- Jae Won Oh (ORCID: https://orcid.org/0000-0002-5379-9907)
Institutions
- Gachon University (KR)
- Yonsei University (KR)
- Severance Hospital (KR)
- University Health System (US)
- Fred Hutch Cancer Center (US)
- Gangnam Severance Hospital (KR)
- CHA University (KR)
- Yonsei University Health System (KR)
- University of Pennsylvania (US)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1016/j.ctro.2025.101069
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Yonsei University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Yonsei University College of Medicine