Regulation of carbonic anhydrase IX gene expression through the LncRNA TRPM2-AS is associated with tumor progression in colorectal tumors
LncRNATRPM2-AS can efficiently control hypoxia in CRC cells by targeting CAIX. This is evidenced by showing the overexpression of lncRNA and CAIX in CRC tumors as well as the suppressive effects of lncRNA TRPM2-AS on CAIX expression in the HCT116 cell line. This data suggests CAIX down-regulation by lncRNA TRPM2, as a therapeutic target to suppress hypoxia-related progression and drug resistance in tumor cells.
Authors
- Abdolamir Allameh (ORCID: https://orcid.org/0000-0003-0757-9572)
- Samane Sharif (ORCID: https://orcid.org/0000-0001-5002-7453)
- Baratali Mashkani (ORCID: https://orcid.org/0000-0002-7606-5455)
- M R Abbaszadegan
- Marziye Emamian
Institutions
- Tarbiat Modares University (IR)
- Mashhad University of Medical Sciences (IR)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1007/s12672-025-04126-2
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00