Menthol’s disruptive effects on kanamycin-resistant Escherichia coli energy metabolism and ion fluxes
The presented study aimed to investigate the antibacterial activity of menthol-the main component of one of the widespread plants of the Lamiaceae family-Mentha arvensis. To investigate the mode of action of menthol, we studied its influence on kanamycin-resistant E. coli pARG-25 and wild-type E. coli BW25113 strains. For this, the effect of menthol on ATPase activity, proton and potassium fluxes, and intracellular pH was investigated under aerobic and anaerobic conditions. The results showed that menthol influences these parameters in a concentration- and condition-dependent way. It likely interacts with FoF<sub>1</sub>-ATPase and other systems involved in energy-generating processes and ion transport, disrupting the bacterial metabolism of both antibiotic-resistant and -susceptible strains.
Authors
- Hovakim Grabski (ORCID: https://orcid.org/0000-0001-6115-9339)
- Siranuysh Grabska (ORCID: https://orcid.org/0000-0001-9291-3357)
- Ruben Abagyan (ORCID: https://orcid.org/0000-0001-9309-2976)
- Naira Zh. Sahakyan (ORCID: https://orcid.org/0000-0002-7370-1380)
- Karen A. Trchounian (ORCID: https://orcid.org/0000-0002-6624-8936)
- Silvard Tadevosyan (ORCID: https://orcid.org/0009-0005-3818-7274)
Institutions
- University of Montana (US)
- National Academy of Sciences of Armenia (AM)
Publication Details
- Journal
- Biophysical Reports
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1016/j.bpr.2025.100240
- Citations
- 1
- Primary Topic
- Essential Oils and Antimicrobial Activity
- Type
- article
- Field-Weighted Citation Impact
- 1.16